Our research aims to ensure adequate statistical power to detect associations between risk factors and cognitive outcomes, such as Alzheimer’s Disease and Related Dementias (ADRD). These considerations are crucial for building a research infrastructure capable of generating reliable and valid results in Nepal.
Based on prior data, we estimate a 15% prevalence for cognitive impairment in the rural setting of Chitwan Valley and a 5% prevalence for ADRD.
With a sample size of 4,000 and a 5% significance level, we expect to have adequate power to detect associations for various risk factors. Power calculations show good capability for detecting sex-specific effects and other significant variables.
Since previous studies have shown mixed results regarding sex differences in ADRD risk, we will explore sex-specific models and interaction effects between sex and predictor variables to understand these differences in the Nepali population.